| Narcolepsy is closely linked to the loss of hypocretin (orexin)-producing neurons in the brain, which play a key role in maintaining wakefulness. Genetic studies have identified variations in the T-cell receptor (TCR) genes, suggesting that an autoimmune attack against these neurons could be responsible for hypocretin deficiency.
Additionally, mutations in the P2RY11 gene, involved in immune regulation, have been linked to increased susceptibility to narcolepsy. These findings further support the autoimmune hypothesis, where genetic predisposition combined with environmental triggers (such as infections) may contribute to neuron loss. |
